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METHOD DETAILS Antibodies and reagents Antibodies against the following proteins were used (See also Key Resource Table): Cell Signaling: FOXO1 (2880), FOXO4 (9472), Phospho-Ser15 p53 (9286), PUMA (4976), BIM (C3C5), Cleaved Caspase-3 (9661), Sigma: FOXO4 (HPA040232), Tubulin (clone B512

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Presently, our understanding allows us to assert that the predominant methods of radiotherapy and cytostatic drugs may induce cellular senescence [54]